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U1A Protein – Stem Loop 2 RNA Recognition: Prediction of Structural Differences from Protein Mutations

Molecular dynamics (MD) simulations were carried out to compare the free and bound structures of wild type U1A protein with several Phe56 mutant U1A proteins that bind the target stem loop 2 (SL2) RNA with a range of affinities. The simulations indicate the free U1A protein is more flexible than the...

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書誌詳細
主要な著者: Kormos, Bethany L., Pieniazek, Susan N., Beveridge, David L., Baranger, Anne M.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732173/
https://ncbi.nlm.nih.gov/pubmed/21384338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21616
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