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Affinity and Specificity of Protein U1A-RNA Complex Formation Based on an Additive Component Free Energy Model

A MM-GBSA computational protocol was used successfully to account for wild type U1A-RNA and F56 U1A mutant experimental binding free energies. The trend in mutant binding free energies compared to wild type is well-reproduced. Following application of a linear-response-like equation to scale the var...

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Bibliografske podrobnosti
Main Authors: Kormos, Bethany L., Benitex, Yulia, Baranger, Anne M., Beveridge, David L.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034351/
https://ncbi.nlm.nih.gov/pubmed/17603075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.06.003
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