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U1A Protein – Stem Loop 2 RNA Recognition: Prediction of Structural Differences from Protein Mutations
Molecular dynamics (MD) simulations were carried out to compare the free and bound structures of wild type U1A protein with several Phe56 mutant U1A proteins that bind the target stem loop 2 (SL2) RNA with a range of affinities. The simulations indicate the free U1A protein is more flexible than the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3732173/ https://ncbi.nlm.nih.gov/pubmed/21384338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21616 |
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