Targeted Modifications in Adeno-Associated Virus Serotype 8 Capsid Improves Its Hepatic Gene Transfer Efficiency In Vivo

Recombinant adeno-associated virus vectors based on serotype 8 (AAV8) have shown significant promise for liver-directed gene therapy. However, to overcome the vector dose dependent immunotoxicity seen with AAV8 vectors, it is important to develop better AAV8 vectors that provide enhanced gene expres...

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Detalhes bibliográficos
Main Authors: Sen, Dwaipayan, Gadkari, Rupali A, Sudha, Govindarajan, Gabriel, Nishanth, Kumar, Yesupatham Sathish, Selot, Ruchita, Samuel, Rekha, Rajalingam, Sumathi, Ramya, V., Nair, Sukesh C., Srinivasan, Narayanaswamy, Srivastava, Alok, Jayandharan, Giridhara R.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732127/
https://ncbi.nlm.nih.gov/pubmed/23442071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.195
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