Bioengineering of AAV2 Capsid at Specific Serine, Threonine, or Lysine Residues Improves Its Transduction Efficiency in Vitro and in Vivo

We hypothesized that the AAV2 vector is targeted for destruction in the cytoplasm by the host cellular kinase/ubiquitination/proteasomal machinery and that modification of their targets on AAV2 capsid may improve its transduction efficiency. In vitro analysis with pharmacological inhibitors of cellu...

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Detalhes bibliográficos
Main Authors: Gabriel, Nishanth, Hareendran, Sangeetha, Sen, Dwaipayan, Gadkari, Rupali A., Sudha, Govindarajan, Selot, Ruchita, Hussain, Mansoor, Dhaksnamoorthy, Ramya, Samuel, Rekha, Srinivasan, Narayanaswamy, Srivastava, Alok, Jayandharan, Giridhara R.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732126/
https://ncbi.nlm.nih.gov/pubmed/23379478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.194
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