Bioengineering of AAV2 Capsid at Specific Serine, Threonine, or Lysine Residues Improves Its Transduction Efficiency in Vitro and in Vivo

We hypothesized that the AAV2 vector is targeted for destruction in the cytoplasm by the host cellular kinase/ubiquitination/proteasomal machinery and that modification of their targets on AAV2 capsid may improve its transduction efficiency. In vitro analysis with pharmacological inhibitors of cellu...

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Bibliographische Detailangaben
Hauptverfasser: Gabriel, Nishanth, Hareendran, Sangeetha, Sen, Dwaipayan, Gadkari, Rupali A., Sudha, Govindarajan, Selot, Ruchita, Hussain, Mansoor, Dhaksnamoorthy, Ramya, Samuel, Rekha, Srinivasan, Narayanaswamy, Srivastava, Alok, Jayandharan, Giridhara R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2013
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732126/
https://ncbi.nlm.nih.gov/pubmed/23379478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.194
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