Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy

Despite significant advancements with recombinant AAV2 or AAV8 vectors for liver directed gene therapy in humans, it is well-recognized that host and vector-related immune challenges need to be overcome for long-term gene transfer. To overcome these limitations, alternate AAV serotypes (1–10) are be...

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Main Authors: Sen, Dwaipayan, Balakrishnan, Balaji, Gabriel, Nishanth, Agrawal, Prachi, Roshini, Vaani, Samuel, Rekha, Srivastava, Alok, Jayandharan, Giridhara R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652085/
https://ncbi.nlm.nih.gov/pubmed/23665951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01832
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