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Structural studies of Wnts and identification of an LRP6 binding site
Wnts are secreted growth factors that have critical roles in cell fate determination and stem cell renewal. The Wnt/β-catenin pathway is initiated by binding of a Wnt protein to a Frizzled (Fzd) receptor and a co-receptor, LDL receptor-related protein 5 or 6 (LRP5/6). We report the 2.1Å resolution c...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3731992/ https://ncbi.nlm.nih.gov/pubmed/23791946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.05.006 |
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