Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29

Eukaryotic translation initiation begins with assembly of a 43S preinitiation complex. First, Met-tRNA(i)(Met), eukaryotic initiation factor 2 (eIF2) and GTP form a ternary complex (TC). The TC, eIF3, eIF1 and eIF1A cooperatively bind to the 40S subunit yielding the 43S preinitiation complex, which...

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Main Authors: Hashem, Yaser, des Georges, Amedee, Dhote, Vidya, Langlois, Robert, Liao, Hstau Y., Grassucci, Robert A., Hellen, Christopher U.T., Pestova, Tatyana V., Frank, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730827/
https://ncbi.nlm.nih.gov/pubmed/23706745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.036
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