Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models

Amyloid-β (Aβ) peptides, starting with pyroglutamate at the third residue (pyroGlu-3 Aβ), are a major species deposited in the brain of Alzheimer disease (AD) patients. Recent studies suggest that this isoform shows higher toxicity and amyloidogenecity when compared to full-length Aβ peptides. Here,...

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Main Authors: Frost, Jeffrey L., Le, Kevin X., Cynis, Holger, Ekpo, Elizabeth, Kleinschmidt, Martin, Palmour, Roberta M., Ervin, Frank R., Snigdha, Shikha, Cotman, Carl W., Saido, Takaomi C., Vassar, Robert J., George-Hyslop, Peter St., Ikezu, Tsuneya, Schilling, Stephan, Demuth, Hans-Ulrich, Lemere, Cynthia A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2013
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730768/
https://ncbi.nlm.nih.gov/pubmed/23747948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.05.005
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