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Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

Immunization against amyloid-β (Aβ) peptides deposited in Alzheimer’s disease (AD) has shown considerable therapeutic effect in animal models however, the translation into human Alzheimer’s patients is challenging. In recent years, a number of promising Aβ immunotherapy trials failed to reach primar...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Cynis, Holger, Frost, Jeffrey L., Crehan, Helen, Lemere, Cynthia A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929720/
https://ncbi.nlm.nih.gov/pubmed/27363697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0115-2
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