Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

We have recently shown that the crosstalk between mild endoplasmic reticulum (ER) stress and low concentrations of the pro-inflammatory cytokine interleukin (IL)-1β exacerbates beta cell inflammatory responses via the IRE1α/XBP1 pathway. We presently investigated whether mild ER stress also sensitiz...

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Hlavní autoři: Miani, M, Barthson, J, Colli, M L, Brozzi, F, Cnop, M, Eizirik, D L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730410/
https://ncbi.nlm.nih.gov/pubmed/23828564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.236
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