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Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis

OBJECTIVES: Interferon beta (IFNβ) therapy is effective in multiple sclerosis and murine models of arthritis. Surprisingly, systemic IFNβ treatment induces only minimal improvement in rheumatoid arthritis (RA). To explain this paradox, the authors evaluated the mechanism of IFNβ benefit in passive K...

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Hlavní autoři: Corr, Maripat, Boyle, David L, Ronacher, Lisa M, Lew, Brian R, van Baarsen, Lisa G, Tak, Paul P, Firestein, Gary S
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728888/
https://ncbi.nlm.nih.gov/pubmed/21216819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2010.141077
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