Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis

OBJECTIVES: Interferon beta (IFNβ) therapy is effective in multiple sclerosis and murine models of arthritis. Surprisingly, systemic IFNβ treatment induces only minimal improvement in rheumatoid arthritis (RA). To explain this paradox, the authors evaluated the mechanism of IFNβ benefit in passive K...

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Main Authors: Corr, Maripat, Boyle, David L, Ronacher, Lisa M, Lew, Brian R, van Baarsen, Lisa G, Tak, Paul P, Firestein, Gary S
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728888/
https://ncbi.nlm.nih.gov/pubmed/21216819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2010.141077
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