Synthesis and Biological Activity of 2-Aminothiazoles as Novel Inhibitors of PGE(2) Production in Cells

This report presents the synthesis and biological evaluation of a collection of 2-aminothiazoles as a novel class of compounds with the capability to reduce the production of PGE(2) in HCA-7 human adenocarcinoma cells. A total of 36 analogs were synthesized and assayed for PGE(2) reduction, and thos...

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Hlavní autoři: Smith, Breland, Chang, Hui-Hua, Medda, Federico, Gokhale, Vijay, Dietrich, Justin, Davis, Angela, Meuillet, Emmanuelle J., Hulme, Christopher
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727903/
https://ncbi.nlm.nih.gov/pubmed/22516282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.03.013
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