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Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

[Image: see text] With 24.3 million people affected in 2005 and an estimated rise to 42.3 million in 2020, dementia is currently a leading unmet medical need and costly burden on public health. Seventy percent of these cases have been attributed to Alzheimer’s disease (AD), a neurodegenerative patho...

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Detalhes bibliográficos
Main Authors: Smith, Breland, Medda, Federico, Gokhale, Vijay, Dunckley, Travis, Hulme, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503344/
https://ncbi.nlm.nih.gov/pubmed/23173067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300094k
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