Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE(2) production in cells

This article reports the synthesis and biological evaluation of a collection of aminophthalazines as a novel class of compounds capable of reducing production of PGE(2) in HCA-7 human adenocarcinoma cells. A total of 28 analogs were synthesized, assayed for PGE(2) reduction, and selected active comp...

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Detalhes bibliográficos
Main Authors: Medda, Federico, Sells, Earlphia, Chang, Hui-Hua, Dietrich, Justin, Chappeta, Shashi, Smith, Breland, Gokhale, Vijay, Meuillet, Emmanuelle J., Hulme, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534862/
https://ncbi.nlm.nih.gov/pubmed/23237838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.11.030
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