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Concise Preparation of Novel Tricyclic Chemotypes: Fused Hydantoin-benzodiazepines

The following article describes a concise synthesis of a collection of 4,5-dihydro-1H-benzo[e][1,4]diazepines fused to a hydantoin ring. Molecular complexity and biological relevance is high and structures are generated in a mere three steps, employing the Ugi reaction to assemble diversity reagents...

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Detalhes bibliográficos
Main Authors: Gunawan, Steven, Nichol, Gary S., Chappeta, Shashi, Dietrich, Justin, Hulme, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928152/
https://ncbi.nlm.nih.gov/pubmed/20802841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.06.131
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