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Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade

Dihydropyrazino-quinazolinedione chemotypes are complex and structurally challenging structures of biological interest, being found in the marine alkaloids such as brevianamide M-N and fumiquinazolines A-C. Herein we report the synthesis of this tricyclic system in three synthetic operations by mean...

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Detalhes bibliográficos
Main Authors: Gunawan, Steven, Hulme, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755472/
https://ncbi.nlm.nih.gov/pubmed/23997316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.06.042
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