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Hydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazoles

This report discloses a novel concise synthesis of a series of 3-hydroxypyrazoles 5 via a tandem Ugi/debenzylation /hydrazine-mediated cyclization sequence. Herein, n-butyl isocyanide 4b was utilized as an alternative to classical convertible isocyanides enabling high yielding hydrazine-mediated cyc...

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Bibliografski detalji
Glavni autori: Shaw, Arthur Y., McLaren, Jonathan A., Nichol, Gary S., Hulme, Christopher
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337763/
https://ncbi.nlm.nih.gov/pubmed/22544981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2012.03.033
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