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Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans

The design and synthesis of a library of forty novel 2-aminoazole analogues as well as their evaluation as antifungal compounds against Histoplasma capsulatum and Cryptococcus neoformans is described. These structures were derived from N-[5-(1-naphthalenylmethyl)-2-thiazolyl]cyclohexanecarboxamide (...

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Ishita, Keisuke, Stefanopoulos, Stavros, Khalil, Ahmed, Cheng, Xiaolin, Tjarks, Werner, Rappleye, Chad A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935597/
https://ncbi.nlm.nih.gov/pubmed/29580849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.01.024
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