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Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

BACKGROUND: Dysfunction of regulatory T (Treg) cells has been detected in diverse inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is critical for Treg cell growth, survival, and activity. We hypothesized that low-dose interleukin-2 could preferentially enhan...

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Detalhes bibliográficos
Main Authors: Koreth, John, Matsuoka, Ken-ichi, Kim, Haesook T., McDonough, Sean M., Bindra, Bhavjot, Alyea, Edwin P., Armand, Philippe, Cutler, Corey, Ho, Vincent T., Treister, Nathaniel S., Bienfang, Don C., Prasad, Sashank, Tzachanis, Dmitrios, Joyce, Robin M., Avigan, David E., Antin, Joseph H., Ritz, Jerome, Soiffer, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727432/
https://ncbi.nlm.nih.gov/pubmed/22129252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1108188
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