Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations

Ion channels of the DEG/ENaC family can induce neurodegeneration under conditions in which they become hyperactivated. The Caenorhabditis elegans DEG/ENaC channel MEC-4(d) encodes a mutant channel with a substitution in the pore domain that causes swelling and death of the six touch neurons in which...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Wang, Ying, Matthewman, Cristina, Han, Lu, Miller, Tyne, Miller, David M., Bianchi, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727304/
https://ncbi.nlm.nih.gov/pubmed/23898007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201310974
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky