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PD-1 and CTLA-4 inhibitory co-signaling pathways in HIV infection and the potential for therapeutic intervention

The balance between proinflammatory mechanisms and dampening of excessive immune activation is critical for successful clearance of a pathogen without harm to the host. In particular, molecules of the B7:CD28 family play a critical role in regulating T cell activation and peripheral tolerance. Chron...

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Bibliografiske detaljer
Main Authors: Kaufmann, Daniel E., Walker, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726306/
https://ncbi.nlm.nih.gov/pubmed/19414738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803771
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