The CTLA-4 and PD-1/PD-L1 Inhibitory Pathways Independently Regulate Host Resistance to Plasmodium-induced Acute Immune Pathology

The balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections. This balance is maintained in part by the negative regulators of T cell activation, CTLA-4 and PD-1/PD-L, which dampen effecto...

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Detalhes bibliográficos
Main Authors: Hafalla, Julius Clemence R., Claser, Carla, Couper, Kevin N., Grau, Georges Emile, Renia, Laurent, de Souza, J. Brian, Riley, Eleanor M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271068/
https://ncbi.nlm.nih.gov/pubmed/22319445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002504
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