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PD-1 and CTLA-4 inhibitory co-signaling pathways in HIV infection and the potential for therapeutic intervention
The balance between proinflammatory mechanisms and dampening of excessive immune activation is critical for successful clearance of a pathogen without harm to the host. In particular, molecules of the B7:CD28 family play a critical role in regulating T cell activation and peripheral tolerance. Chron...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3726306/ https://ncbi.nlm.nih.gov/pubmed/19414738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803771 |
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