PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

Combined immunotherapy targeting the immune checkpoint receptors cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), or CTLA-4 and the PD-1 ligand (PD-L1) exhibits superior anti-tumor responses compared with single-agent therapy. Here, we examined the molecular b...

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Publicado no:Immunity
Main Authors: Zhao, Yunlong, Lee, Calvin K., Lin, Chia-Hao, Gassen, Rodrigo B., Xu, Xiaozheng, Huang, Zhe, Xiao, Changchun, Bonorino, Cristina, Lu, Li-Fan, Bui, Jack D., Hui, Enfu
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935268/
https://ncbi.nlm.nih.gov/pubmed/31757674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.11.003
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