Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?

CD28 and CTLA-4 are prototypal co-stimulatory and co-inhibitory cell surface signaling molecules interacting with CD80/86, known to be critical for immune response initiation and regulation, respectively. Initial “bench-to-beside” translation, two decades ago, resulted in the development of CTLA4-Ig...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Ville, Simon, Poirier, Nicolas, Blancho, Gilles, Vanhove, Bernard
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532816/
https://ncbi.nlm.nih.gov/pubmed/26322044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00411
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