Inactivation of specific β cell transcription factors in type 2 diabetes

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance. Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative stress, a condition associated with β cell dysfunction in both type 1 diabetes (T1DM) and T2DM. Hydrogen peroxide treatm...

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Main Authors: Guo, Shuangli, Dai, Chunhua, Guo, Min, Taylor, Brandon, Harmon, Jamie S., Sander, Maike, Robertson, R. Paul, Powers, Alvin C., Stein, Roland
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726150/
https://ncbi.nlm.nih.gov/pubmed/23863625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65390
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