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Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels

ATP-gated P2X receptors and acid-sensing ion channels are cation-selective, trimeric ligand-gated ion channels unrelated in amino acid sequence. Nevertheless, initial crystal structures of the P2X4 receptor and acid-sensing ion channel 1a in resting/closed and in non conductive/desensitized conforma...

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Autors principals: Baconguis, Isabelle, Hattori, Motoyuki, Gouaux, Eric
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725955/
https://ncbi.nlm.nih.gov/pubmed/23628284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2013.04.005
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