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X-ray structure of acid-sensing ion channel 1–snake toxin complex reveals open state of a Na(+)-selective channel

Acid sensing ion channels (ASICs) detect extracellular protons produced during inflammation or ischemic injury and belong to the super family of degenerin/epithelial sodium channels. Here, we determine the cocrystal structure of chicken ASIC1a with MitTx, a pain-inducing toxin from the Texas coral s...

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Autori principali: Baconguis, Isabelle, Bohlen, Christopher J., Goehring, April, Julius, David, Gouaux, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190031/
https://ncbi.nlm.nih.gov/pubmed/24507937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.011
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