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Structural plasticity and dynamic selectivity of acid sensing ion channel–toxin complexes

Acid sensing ion channels (ASICs) are voltage-independent, amiloride-sensitive channels implicated in diverse physiological processes ranging from nociception to taste. Despite the importance of ASICs in physiology, we know little about the mechanism of channel activation. Here we show that psalmoto...

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Detalhes bibliográficos
Main Authors: Baconguis, Isabelle, Gouaux, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725952/
https://ncbi.nlm.nih.gov/pubmed/22842900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11375
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