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Development and validation of a high throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors
The kinase MEKK2 (MAP3K2) has recently been implicated in tumor growth and metastasis. Thus, selective inhibition of MEKK2 may be a novel strategy for cancer therapy. In order to identify inhibitors of MEKK2 kinase activity, we have developed a novel activity assay for MEKK2 based on the discovery t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3723327/ https://ncbi.nlm.nih.gov/pubmed/23134735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112466430 |
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