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High-Throughput HIV–Cell Fusion Assay for Discovery of Virus Entry Inhibitors
HIV-1 initiates infection by merging its envelope membrane with the target cell membrane, a process that is mediated by the viral Env glycoprotein following its sequential binding to CD4 and coreceptors, CXCR4 or CCR5. Although HIV-1 fusion has been a target for antiviral therapy, the virus has deve...
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| Publicado no: | Assay Drug Dev Technol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4410757/ https://ncbi.nlm.nih.gov/pubmed/25871547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2015.639 |
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