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High-Throughput HIV–Cell Fusion Assay for Discovery of Virus Entry Inhibitors

HIV-1 initiates infection by merging its envelope membrane with the target cell membrane, a process that is mediated by the viral Env glycoprotein following its sequential binding to CD4 and coreceptors, CXCR4 or CCR5. Although HIV-1 fusion has been a target for antiviral therapy, the virus has deve...

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Détails bibliographiques
Publié dans:Assay Drug Dev Technol
Auteurs principaux: Marin, Mariana, Du, Yuhong, Giroud, Charline, Kim, Jeong Hwa, Qui, Min, Fu, Haian, Melikyan, Gregory B.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410757/
https://ncbi.nlm.nih.gov/pubmed/25871547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2015.639
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