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A Novel High-Throughput Screening Assay for Discovery of Molecules That Increase Cellular Tetrahydrobiopterin

Tetrahydrobiopterin (BH(4)) is an essential cofactor for the nitric oxide (NO) synthases and the aromatic amino acid hydroxylases. Insufficient BH(4) has been implicated in various cardiovascular and neurological disorders. GTP cyclohydrolase 1 (GTPCH-1) is the rate-limiting enzyme for de novo biosy...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biomol Screen
Päätekijät: LI, LI, DU, YUHONG, CHEN, WEI, FU, HAIAN, HARRISON, DAVID G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677475/
https://ncbi.nlm.nih.gov/pubmed/21693765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057111411088
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