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A Novel High-Throughput Screening Assay for Discovery of Molecules That Increase Cellular Tetrahydrobiopterin

Tetrahydrobiopterin (BH(4)) is an essential cofactor for the nitric oxide (NO) synthases and the aromatic amino acid hydroxylases. Insufficient BH(4) has been implicated in various cardiovascular and neurological disorders. GTP cyclohydrolase 1 (GTPCH-1) is the rate-limiting enzyme for de novo biosy...

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Bibliografiske detaljer
Udgivet i:J Biomol Screen
Main Authors: LI, LI, DU, YUHONG, CHEN, WEI, FU, HAIAN, HARRISON, DAVID G.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677475/
https://ncbi.nlm.nih.gov/pubmed/21693765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057111411088
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