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P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions

HIV-1 Env glycoprotein-mediated fusion is initiated upon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5. Whereas these interactions are thought to be necessary and sufficient to promote HIV-1 fusion, other host factors can modulate this process. Previous studies reported potent in...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Giroud, Charline, Marin, Mariana, Hammonds, Jason, Spearman, Paul, Melikyan, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542394/
https://ncbi.nlm.nih.gov/pubmed/26136569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01178-15
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