Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2)

The kinase MEKK2 (MAP3K2) activates the MEK5/ERK5 cell signaling pathway and may play an important role in tumor growth and metastasis. Thus, MEKK2 may represent a novel kinase target for cancer. In order to identify inhibitors of MEKK2, we screened a library of compounds using a high throughput MEK...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Ahmad, Syed, St Hilaire, Valentine R., Dandepally, Srinivasa R., Johnson, Gary L., Williams, Alfred L., Scott, John E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784828/
https://ncbi.nlm.nih.gov/pubmed/29309787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.01.027
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