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Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2)
The kinase MEKK2 (MAP3K2) activates the MEK5/ERK5 cell signaling pathway and may play an important role in tumor growth and metastasis. Thus, MEKK2 may represent a novel kinase target for cancer. In order to identify inhibitors of MEKK2, we screened a library of compounds using a high throughput MEK...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5784828/ https://ncbi.nlm.nih.gov/pubmed/29309787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.01.027 |
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