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HER3 signaling is regulated through a multitude of redundant mechanisms in HER2-driven tumor cells
HER2-amplified tumors are characterized by constitutive signaling via the HER2-HER3 co-receptor complex. While phosphorylation activity is driven entirely by the HER2 kinase, signal volume generated by the complex is under control of HER3 and a large capacity to increase its signaling output account...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3722874/ https://ncbi.nlm.nih.gov/pubmed/22853430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120724 |
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