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Resiliency and vulnerability in the HER2-HER3 tumorigenic driver
About 25% of breast cancers harbor the amplified oncogene HER2 and are dependent on HER2 kinase function, identifying HER2 as a vulnerable target for therapy. However,. HER2-HER3 activation is buffered so that it is protected against a nearly two log inhibition of HER2 catalytic activity; this buffe...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033659/ https://ncbi.nlm.nih.gov/pubmed/20371474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000389 |
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