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A TORC2-Akt feedforward topology underlies HER3 resiliency in HER2-amplified cancers

The requisite role of HER3 in HER2-amplified cancers is beyond what would be expected as a dimerization partner or effector substrate and it exhibits a substantial degree of resiliency that mitigates the effects of HER2-inhibitor therapies. To better understand the roots of this resiliency, we condu...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Amin, Dhara N., Ahuja, Deepika, Yaswen, Paul, Moasser, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674361/
https://ncbi.nlm.nih.gov/pubmed/26438156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0403
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