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Single-molecule studies reveal the function of a third polymerase in the replisome
The Escherichia coli replisome contains three polymerases, one more than necessary to duplicate the two parental strands. Using single-molecule studies, we reveal two advantages conferred by the third polymerase. First, dipolymerase replisomes are inefficient at synthesizing lagging strands, leaving...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3721970/ https://ncbi.nlm.nih.gov/pubmed/22157955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2179 |
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