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Single-molecule studies reveal the function of a third polymerase in the replisome

The Escherichia coli replisome contains three polymerases, one more than necessary to duplicate the two parental strands. Using single-molecule studies, we reveal two advantages conferred by the third polymerase. First, dipolymerase replisomes are inefficient at synthesizing lagging strands, leaving...

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Bibliografske podrobnosti
Main Authors: Georgescu, Roxana E, Kurth, Isabel, O'Donnell, Mike E
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721970/
https://ncbi.nlm.nih.gov/pubmed/22157955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2179
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