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A solution to release twisted DNA during chromosome replication by coupled DNA polymerases

Chromosomal replication machines contain coupled DNA polymerases that simultaneously replicate the leading and lagging strands(1). However, coupled replication presents a largely unrecognized topological problem. Since DNA polymerase must travel a helical path during synthesis, the physical connecti...

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Detalles Bibliográficos
Main Authors: Kurth, Isabel, Georgescu, Roxana E., O’Donnell, Mike
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618558/
https://ncbi.nlm.nih.gov/pubmed/23535600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11988
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