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A solution to release twisted DNA during chromosome replication by coupled DNA polymerases
Chromosomal replication machines contain coupled DNA polymerases that simultaneously replicate the leading and lagging strands(1). However, coupled replication presents a largely unrecognized topological problem. Since DNA polymerase must travel a helical path during synthesis, the physical connecti...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3618558/ https://ncbi.nlm.nih.gov/pubmed/23535600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11988 |
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