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A solution to release twisted DNA during chromosome replication by coupled DNA polymerases
Chromosomal replication machines contain coupled DNA polymerases that simultaneously replicate the leading and lagging strands(1). However, coupled replication presents a largely unrecognized topological problem. Since DNA polymerase must travel a helical path during synthesis, the physical connecti...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3618558/ https://ncbi.nlm.nih.gov/pubmed/23535600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11988 |
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