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Mechanism of polymerase collision release from sliding clamps on the lagging strand
Replicative polymerases are tethered to DNA by sliding clamps for processive DNA synthesis. Despite attachment to a sliding clamp, the polymerase on the lagging strand must cycle on and off DNA for each Okazaki fragment. In the ‘collision release' model, the lagging strand polymerase collides w...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760110/ https://ncbi.nlm.nih.gov/pubmed/19696739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.233 |
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