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Mechanism of polymerase collision release from sliding clamps on the lagging strand

Replicative polymerases are tethered to DNA by sliding clamps for processive DNA synthesis. Despite attachment to a sliding clamp, the polymerase on the lagging strand must cycle on and off DNA for each Okazaki fragment. In the ‘collision release' model, the lagging strand polymerase collides w...

詳細記述

保存先:
書誌詳細
主要な著者: Georgescu, Roxana E, Kurth, Isabel, Yao, Nina Y, Stewart, Jelena, Yurieva, Olga, O'Donnell, Mike
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760110/
https://ncbi.nlm.nih.gov/pubmed/19696739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.233
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