Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases

BACKGROUND: While genome-wide association studies (GWAS) of complex traits have revealed thousands of reproducible genetic associations to date, these loci collectively confer very little of the heritability of their respective diseases and, in general, have contributed little to our understanding t...

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Hlavní autoři: Lee, Younghee, Li, Haiquan, Li, Jianrong, Rebman, Ellen, Achour, Ikbel, Regan, Kelly E, Gamazon, Eric R, Chen, James L, Yang, Xinan Holly, Cox, Nancy J, Lussier, Yves A
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2013
Témata:
Focus on Translational Bioinformatics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721168/
https://ncbi.nlm.nih.gov/pubmed/23355459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/amiajnl-2012-001519
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