Distinction between the Cfr Methyltransferase Conferring Antibiotic Resistance and the Housekeeping RlmN Methyltransferase

The cfr gene encodes the Cfr methyltransferase that primarily methylates C-8 in A2503 of 23S rRNA in the peptidyl transferase region of bacterial ribosomes. The methylation provides resistance to six classes of antibiotics of clinical and veterinary importance. The rlmN gene encodes the RlmN methylt...

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Bibliographic Details
Main Authors: Atkinson, Gemma C., Hansen, Lykke H., Tenson, Tanel, Rasmussen, Anette, Kirpekar, Finn, Vester, Birte
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719738/
https://ncbi.nlm.nih.gov/pubmed/23752511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00448-13
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