Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

The Cfr methyltransferase confers combined resistance to five different classes of antibiotics that bind to the peptidyl transferase center of bacterial ribosomes. The Cfr-mediated modification has previously been shown to occur on nucleotide A2503 of 23S rRNA and has a mass corresponding to an addi...

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Main Authors: Giessing, Anders Michael Bernth, Jensen, Søren Skov, Rasmussen, Anette, Hansen, Lykke Haastrup, Gondela, Andrzej, Long, Katherine, Vester, Birte, Kirpekar, Finn
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648713/
https://ncbi.nlm.nih.gov/pubmed/19144912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1371409
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