Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

The Cfr methyltransferase confers combined resistance to five classes of antibiotics that bind to the peptidyl tranferase center of bacterial ribosomes by catalyzing methylation of the C-8 position of 23S rRNA nucleotide A2503. The same nucleotide is targeted by the housekeeping methyltransferase Rl...

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Detalhes bibliográficos
Main Authors: Kaminska, Katarzyna H., Purta, Elzbieta, Hansen, Lykke H., Bujnicki, Janusz M., Vester, Birte, Long, Katherine S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836569/
https://ncbi.nlm.nih.gov/pubmed/20007606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1142
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