Tissue-Nonspecific Alkaline Phosphatase Acts Redundantly with PAP and NT5E to Generate Adenosine in the Dorsal Spinal Cord

Prostatic acid phosphatase (PAP) and ecto-5′-nucleotidase (NT5E) hydrolyze extracellular AMP to adenosine in dorsal root ganglia (DRG) neurons and in the dorsal spinal cord. Previously, we found that adenosine production was reduced, but not eliminated, in Pap(−/−)/Nt5e(−/−) double knock-out (dKO) m...

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Auteurs principaux: Street, Sarah E., Kramer, Nicholas J., Walsh, Paul L., Taylor-Blake, Bonnie, Yadav, Manisha C., King, Ian F., Vihko, Pirkko, Wightman, R. Mark, Millán, José Luis, Zylka, Mark J.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718384/
https://ncbi.nlm.nih.gov/pubmed/23825434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0133-13.2013
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